Sleep: Never Wasted but Often Too Short

Pituitary incidentalomas - How often is too often?

INTRODUCTION Clinical nonfunctional pituitary microadenomas, also known as incidentalomas are accidental observations made due to the application of high resolution imaging techniques as computed tomography or magnetic resonance. There are no standards regarding the follow-up of these tumors and taking into account their increased frequency among general population (during the last years they w...

Pituitary incidentalomas - How often is too often?

Homocysteine is a sulfurated amino acid used for the synthesis of methionine. The last decade's researches proved that hyperhomocysteinemia is an independent risk factor for atherosclerotic vascular disease. The vascular injury induced by several mechanisms of hyperhomocysteinemia is the hallmark of homocysteine's atherogenic properties. Hyperhomocysteinemia is present in 85% of the patients wi...

Ondine's curse--never too late.

a normal life span. It has recently been shown that CCHS confers risk for adverse neurocognitive outcome [3]. Visuoperceptual reasoning and clerical/ visuographic speed appear particularly vulnerable. In this issue of IMAJ, Cohen-Cymberknoh and colleagues [4] present an interesting and unusual case of a 12 year old girl with late-onset CCHS that was suspected and diagnosed only after she failed...

Case finding of Alpha-1 antitrypsin deficiency: never wasted time!

Alpha-1 Antitrypsin Deficiency (AATD) is considered the most important genetic cause of respiratory disorders, mainly COPD in its emphysematous phenotype [1, 2]. In high risk populations, i.e. those in which a high prevalence of AATD is suspected on the ground of previous data [3], up to 2% of the cases of COPD may, in fact, be due to AATD [4]. This prompted WHO to issue a recommendation that a...

Dementia risk reduction: it's never too early, it's never too late.